Full name:

latexin

Synonyms:

ECI; TCI

Swissprot:

Q9BS40

Gene Accession:

BC005346

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

Latexin, also designated endogenous carboxypeptidase inhibitor (ECI) or tissue carboxypeptidase inhibitor (TCI), belongs to the protease inhibitor I47 family of proteins. Latexin acts as a non-competitive, reversible inhibitor for metallocarboxypeptidases (MCPs), including CPA1, CPA2 and CPA4. It is a cytoplasmic protein that is highly expressed in heart, prostate, pancreas, ovary, kidney, brain and colon. Latexin consists of two topologically equivalent subdomains that bind to MCPs with low specificity, which gives it with the flexibility to inhibit all vertebrate A/B MCPs.